Test whether combining molecular “signals of safety” with bioelectrical reprogramming improves cancer therapy

Determine whether combining molecular signals of safety—physiological cues intended to convey a safe, non-threatening morphostatic state—with bioelectrical topology reprogramming of epithelial tissues increases the therapeutic efficacy of normalizing neoplastic growth compared to bioelectrical reprogramming alone.

Background

The paper proposes a trauma-informed framework for cancer therapy that focuses on reintegrating neoplastic cells into the surrounding tissue’s regulatory architecture rather than destroying them. As part of this approach, prior work is cited showing that modulating the bioelectrical topology of epithelial tissues can normalize tumor-like structures bearing canonical oncogenic mutations (e.g., KRAS, BRAFV600E), which the author interprets as a form of morphogenetic memory reprocessing.

Building on this evidence, the author suggests that therapeutic efficacy might be further improved by combining bioelectrical interventions with molecular signals that convey safety or homeostatic resolution to tissues. This raises a concrete, testable question about the potential additive or synergistic effects of pairing molecular “signals of safety” with bioelectrical reprogramming in order to enhance reintegration and normalization of neoplastic phenotypes.