Mechanistic link between mitochondrial dysfunction and cancer

Elucidate the mechanistic pathways that link mitochondrial dysfunction to carcinogenesis, including the contributions of mitochondrial dynamics, redox homeostasis, and metabolic reprogramming to cancer initiation and progression.

Background

Mitochondria regulate energy production, ROS generation, apoptosis, and metabolism—all processes frequently altered in tumors.

Despite strong correlations and extensive paper, the causal and mechanistic connections remain unresolved, limiting targeted therapeutic strategies.