Conjecture 1.2: Cells couple problem signals to corrective responses

Demonstrate that cells systematically couple sensor-derived problem signals to specific responses that trigger corrective actions aimed at resolving those signals and restoring cellular equilibrium.

Background

Building on the idea that sensor signals represent problems, the authors posit that cells implement mappings from sensed deviations to corrective outputs through adaptable molecular cascade reactions and gene expression changes.

This coupling, potentially modulated through regulation of receptors, channels, and enzymes, is central to their proposal that learning arises from local feedback control rather than global error signals.