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How can we reverse or restore cell function lost during ageing?

Develop and test interventions that reverse or restore age-associated reductions in cell function across tissues, aiming to recuperate youthful cellular performance.

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Background

Targeting the functional decline of cells is central to rejuvenation strategies. The authors include this as a key intervention-focused open problem.

Addressing this question would bridge mechanistic insights and therapeutic development.

References

Table 1: Examples of open problems with significant representation in the literature, categorised by topic. How can we reverse or restore cell function lost during ageing?

— Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Table 1, Results