Which tissues, organs or cell types contribute more to ageing?

Identify which tissues, organs, and specific cell types contribute most to the progression of organismal ageing, and quantify their relative impact on systemic ageing phenotypes.

Background

This question focuses on the differential contribution of tissue and cell types to overall ageing, a key uncertainty for targeting interventions.

The authors highlighted it among widely discussed open problems, indicating strong interest in dissecting tissue-level drivers of ageing.