Which ageing changes in model organisms also change in a similar way in humans?

Identify ageing-related changes observed in model organisms that recapitulate similar changes in humans, and quantify their translatability for human ageing research.

Background

Translational relevance of model organisms is a core concern in ageing research. This problem asks which changes are conserved and relevant to human ageing.

The authors included this among top examples, indicating a persistent need to map cross-species congruence of ageing phenotypes.

References

Table 1: Examples of open problems with significant representation in the literature, categorised by topic. Which ageing changes in model organisms also change in a similar way in humans?

— Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Table 1, Results