What mechanisms determine the longevity of long-lived species?

Elucidate the molecular, cellular, physiological, and evolutionary mechanisms that determine exceptional longevity in long-lived species.

Background

Comparative biology seeks to uncover traits and mechanisms underlying extended longevity. The authors highlight this as a high-interest open problem.

Identifying the determinants of exceptional longevity may reveal protective mechanisms applicable to human ageing.

References

Table 1: Examples of open problems with significant representation in the literature, categorised by topic. What mechanisms determine the longevity of long-lived species?

— Open problems in ageing science: A roadmap for biogerontology  (2507.18602 - Talay et al., 24 Jul 2025) in Table 1, Results