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How can we measure intrinsic biological age in individuals and translate this knowledge into accurate biomarkers of ageing?

Develop and validate methods to measure intrinsic biological age at the individual level and translate these measures into accurate, clinically useful biomarkers of ageing.

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Background

Biomarkers are essential for evaluating ageing and interventions. The authors list this among the well-represented open problems, reflecting intense activity around epigenetic clocks and other measures.

Advances in biomarker accuracy and translatability are crucial for clinical geroscience.

References

Table 1: Examples of open problems with significant representation in the literature, categorised by topic. How can we measure intrinsic biological age in individuals and translate this knowledge into accurate biomarkers of ageing?

— Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Table 1, Results