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What molecular and cellular processes modulate the pace of ageing in mammals?

Characterize the molecular and cellular processes that modulate the pace of ageing in mammals, identifying pathways that accelerate or decelerate ageing trajectories.

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Background

Understanding rate-modifying processes is central for designing interventions that slow or reverse ageing.

The authors list this among the strongly represented open problems, highlighting its relevance across mechanistic and translational research.

References

Table 1: Examples of open problems with significant representation in the literature, categorised by topic. What molecular and cellular processes modulate the pace of ageing in mammals?

— Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Table 1, Results