Precise roles of genes in exceptional longevity

Determine the precise roles of human genes in modulating the probability of achieving exceptional longevity, defined as survival to age 100 or older, for those genes whose contributions are currently unknown, including whether they increase or decrease the likelihood of reaching this age threshold.

Background

The paper compiles genetic variants associated with longevity and organizes them into pathway-based reports. While APOE and FOXO3 have repeatedly shown associations with longevity, many other genes may contribute with smaller effects or through complex interactions.

The authors explicitly note that despite a strong hereditary component to longevity, the specific contributions of many genes to exceptional longevity (age 100+) are still unknown. Clarifying these roles would improve interpretation of personal genomics results and guide preventive strategies and research on pro-longevity interventions.