How can we break through the current human lifespan ceiling of 122 years?

Develop strategies and interventions capable of surpassing the current documented human maximum lifespan of 122 years, and establish rigorous criteria to evaluate such breakthroughs.

Background

The current record human lifespan is 122 years. This open problem addresses whether and how this ceiling can be exceeded.

The authors classify it among underrepresented questions, reflecting speculative yet impactful lines of inquiry.

References

Table 2: Examples of open problems with the least representation in literature, categorised by topic. How can we break through the current human lifespan ceiling of 122 years?

— Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Table 2, Results