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Mechanisms by which HSPA genes influence ageing and longevity

Elucidate the molecular mechanisms by which heat-shock protein genes HSPA1L, HSPA1A, HSPA1B, and HSPA14 influence ageing and human longevity, including the pathways through which these genes protect against stress-induced cellular damage and how their variants affect lifespan-related outcomes.

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Background

Heat-shock proteins act as chaperones that protect cells from stress, contributing to processes such as protein folding and apoptosis. The report includes polymorphisms in several HSPA genes due to their potential relevance to healthy ageing.

The authors state that the exact mechanisms connecting HSPA gene activity to ageing and longevity are not fully understood. Resolving these mechanisms could identify intervention targets to promote healthy ageing and extend lifespan.

References

While the exact mechanisms by which HSPA genes influence ageing and longevity are not yet fully understood, it is believed that they may help to protect cells from the accumulation of damage caused by stress and other environmental factors.

— Just-DNA-Seq, open-source personal genomics platform: longevity science for everyone (2403.19087 - Anton et al., 28 Mar 2024) in Subsection: Heat-shock protein genes (within Longevity-enhancing pathways section)