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Impact of gene functions across longevity pathways

Characterize the impact on human longevity of gene functions that are not thoroughly understood within the enumerated pathways—lipid transfer and signalling; insulin/IGF-1 signalling; antioxidant defence; mitochondrial function; sirtuin and mTOR pathways; tumour-suppressor genes; renin-angiotensin system; heat-shock protein genes; inflammation and related pathways; and genome maintenance and post-transcriptional processes—by determining how these gene functions influence lifespan and longevity-associated traits.

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Background

The authors categorize longevity-associated variants into 11 pathway groups to aid interpretation. They emphasize that for many genes within these pathways, functional roles affecting longevity are insufficiently understood.

Improved characterization of these gene functions would enable more accurate longevity risk assessments, enhance pathway-based preventive strategies, and support development of targeted geroprotective therapies.

References

It is important to note that even though the functions of many genes involved in these metabolic pathways are not thoroughly understood in terms of their impact on longevity, gene polymorphisms in these pathways often act as risk factors for age-related diseases.

— Just-DNA-Seq, open-source personal genomics platform: longevity science for everyone (2403.19087 - Anton et al., 28 Mar 2024) in Section: Longevity-enhancing (“pro-longevity”) gene variants and PRSs