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Drivers of ageing remain open to debate

Determine the principal drivers of ageing, distinguishing primary causal mechanisms from secondary or passenger processes, to resolve the ongoing debate in biogerontology.

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Background

The authors explicitly state that identifying the drivers of ageing is a key open question that remains under debate, reinforcing the foundational uncertainty in the field.

Resolving this debate would clarify research priorities and guide intervention strategies targeting ageing mechanisms.

References

This is still a key but major open question in the field as the drivers of ageing remains open to debate 16.

Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Discussion