How much do positive feedback loops and chain reactions contribute to ageing?

Quantify the role of positive feedback loops and chain reactions in amplifying ageing-related damage and dysfunction across biological systems.

Background

Complex systems dynamics may exacerbate ageing through reinforcing loops. This question seeks quantitative understanding of such mechanisms.

The authors list it among underrepresented open problems, highlighting a systems biology gap.

References

Table 2: Examples of open problems with the least representation in literature, categorised by topic. How much do positive feedback loops and chain reactions contribute to ageing?

— Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Table 2, Results