Dice Question Streamline Icon: https://streamlinehq.com

How much do positive feedback loops and chain reactions contribute to ageing?

Quantify the role of positive feedback loops and chain reactions in amplifying ageing-related damage and dysfunction across biological systems.

Information Square Streamline Icon: https://streamlinehq.com

Background

Complex systems dynamics may exacerbate ageing through reinforcing loops. This question seeks quantitative understanding of such mechanisms.

The authors list it among underrepresented open problems, highlighting a systems biology gap.

References

Table 2: Examples of open problems with the least representation in literature, categorised by topic. How much do positive feedback loops and chain reactions contribute to ageing?

— Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Table 2, Results