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Could blood clean-up be used to target ageing processes?

Determine whether blood clean-up approaches (e.g., removal of deleterious circulating factors) can effectively target ageing processes and improve physiological function.

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Background

Systemic factors in blood can modulate ageing phenotypes. This question proposes targeting circulating milieu to influence ageing.

The authors include it among underrepresented open problems, suggesting exploratory therapeutic potential.

References

Table 2: Examples of open problems with the least representation in literature, categorised by topic. Could blood clean-up be used to target ageing processes?

Open problems in ageing science: A roadmap for biogerontology (2507.18602 - Talay et al., 24 Jul 2025) in Table 2, Results