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Interpretation of nanopipette voltage measurements in dendrites and spines

Determine how to interpret voltage signals recorded with nanopipettes in dendrites and dendritic spines, given their improved temporal resolution but limited spatial accuracy.

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Background

Nanopipettes offer high temporal resolution for voltage measurements but sacrifice the spatial resolution necessary to resolve nanoscale structures such as dendrites and dendritic spines.

This limitation leaves ambiguity in how to translate recorded signals into accurate subcellular voltage maps, necessitating methodological or theoretical frameworks to interpret such measurements.

References

A complementary approach uses nanopipettes allowing a better temporal resolution while loosing the necessary spatial accuracy to measure the voltage in dendrites and dendritic spines , with the interpretation of these measurements still unclear.

— Voltage mapping in subcellular nanodomains using electro-diffusion modeling (2407.15697 - Paquin-Lefebvre et al., 22 Jul 2024) in Introduction