Mapping synaptic current to spatial voltage in dendritic spines

Determine how an injected synaptic current is converted into a spatial voltage map within a dendritic spine, accounting for the complex head–neck nano-geometry.

Background

The conversion of synaptic current into voltage within dendritic spines is influenced by narrow necks and head geometries, but the detailed mapping mechanism remains unresolved due to geometric complexity.

The paper presents modeling showing how additional efflux channels can shunt neck resistance, but a comprehensive understanding of current-to-voltage mapping across diverse spine nano-architectures is still lacking.