Exact influence of membrane curvature on local voltage

Characterize the precise influence of membrane curvature on the local voltage distribution in subcellular domains.

Background

Membrane curvature has been proposed to locally modulate voltage, but a quantitative and general characterization has not been established.

The paper investigates this by analyzing domains with oscillating boundaries and comparing simulation results to asymptotic formulas, indicating that curvature can either increase or decrease voltage depending on its sign, yet a complete, general description remains unresolved.