How many diseases of ageing are caused by the trapping of citrate in the mitochondria?

Ascertain the proportion of age-related diseases that are caused, directly or indirectly, by the trapping of citrate in mitochondria, and define the mechanistic pathways involved.

Background

Mitochondrial dysfunction is a hallmark of ageing, and specific metabolic perturbations such as citrate trapping may drive disease.

The authors include this among underrepresented open problems, suggesting a targeted biochemical mechanism worth investigating.