How many diseases of ageing are caused by the trapping of citrate in the mitochondria?

Ascertain the proportion of age-related diseases that are caused, directly or indirectly, by the trapping of citrate in mitochondria, and define the mechanistic pathways involved.

Background

Mitochondrial dysfunction is a hallmark of ageing, and specific metabolic perturbations such as citrate trapping may drive disease.

The authors include this among underrepresented open problems, suggesting a targeted biochemical mechanism worth investigating.

References

Table 2: Examples of open problems with the least representation in literature, categorised by topic. How many diseases of ageing are caused by the trapping of citrate in the mitochondria?

— Open problems in ageing science: A roadmap for biogerontology  (2507.18602 - Talay et al., 24 Jul 2025) in Table 2, Results