Physiological role of inactive ribosomes

Elucidate the functional role of inactive ribosomes in cellular physiology across growth conditions, including their potential sequestration mechanisms and contributions to maintenance or stress response.

Background

Inactive ribosomes are observed especially at slow growth, but their physiological functions and regulation (e.g., sequestration or hibernation factors) remain unclear.

Understanding inactive ribosomes is essential for interpreting offsets in ribosomal growth laws and for modeling translation under stress or slow growth.