Burden of the degradation (protease) sector

Ascertain whether the protease and degradation machinery sector imposes a significant burden on cellular resources and growth across conditions, and quantify associated trade-offs in proteome allocation.

Background

Sector-based proteome models generally treat degradation implicitly; the authors highlight uncertainty about the cost of maintaining the degradation machinery.

Clarifying these burdens would inform optimal allocation strategies under stress, slow growth, or heavy turnover.