Why do cells degrade proteins and when does degradation limit growth?

Investigate the primary drivers of protein degradation (energy conservation versus quality control) and determine under what conditions protein degradation becomes a limiting factor for growth or influences cellular fitness.

Background

Protein degradation is central to proteostasis, with potential roles in energy balance, quality control, and adaptation.

Quantifying its drivers and constraints will improve models of slow growth, maintenance, and stress responses where turnover competes with biosynthesis.