Is mRNA availability a major limiting factor?

Determine whether mRNA availability plays a major limiting role in cellular physiology under steady-state and perturbed conditions, and identify regimes where transcripts co-limit growth alongside ribosomes.

Background

The authors extend growth-law models to transcription, highlighting that mRNA abundance can co-limit translation via initiation.

Establishing when mRNA availability is limiting would refine resource-allocation theories and inform the interpretation of transcriptomics in growth physiology.