Dice Question Streamline Icon: https://streamlinehq.com

Functional role of phosphorylated S6K in facilitating translation

Determine the specific role of phosphorylated ribosomal S6 kinase (S6K) in facilitating mRNA translation, clarifying the mechanisms by which S6K phosphorylation promotes translational initiation or elongation.

Information Square Streamline Icon: https://streamlinehq.com

Background

mTORC1 activates S6K1, which phosphorylates substrates including ribosomal protein S6, eIF4B, and PDCD4, thereby linking growth signals to translation.

Despite extensive mapping of S6K substrates, the review emphasizes that the precise mechanistic contribution of phosphorylated S6K to translation facilitation remains unsettled, even though its inactivation during stress is predicted to inhibit translation.

References

The role of phosphorylated S6K in facilitating translation remains unclear, although its inactivation by mTORC1 during stress is predicted to inhibit translation.

— Stress-induced Eukaryotic Translational Regulatory Mechanisms (2405.01664 - Mir et al., 2 May 2024) in Section 8 (Translation Regulation by mTOR through 4EBP and S6K1)