Rosen’s conjecture on an unknown fundamental principle of life

Identify at least one currently unknown fundamental principle, analogous to those in physics, that underlies living systems and distinguishes them from typical physical systems, consistent with their self-referential, anticipatory, and self-modifying characteristics.

Background

Building on Rosen’s theoretical biology, the paper emphasizes that living systems fundamentally involve self-reference and anticipatory behavior, which challenge the sufficiency of conventional physical laws to explain biological phenomena.

Rosen conjectured the existence of an additional fundamental principle required to account for the distinctive capabilities of life, beyond the standard formal frameworks of physics and computation.