P versus NP equality
Determine whether the deterministic polynomial-time complexity class P equals the nondeterministic polynomial-time class NP; that is, establish whether every decision problem whose solutions can be verified in polynomial time can also be solved in polynomial time.
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References
Briefly, there are huge, century-old open questions in the theory of computer science that would net you fame and fortune if you solved them. One such example is, does P = NP? Another: is NP contained in BQP? We suspect the answer is "no" to both of these questions, but there is currently no mathematical proof.
— What You Shouldn't Know About Quantum Computers
(2405.15838 - Ferrie, 24 May 2024) in Myth 5: Quantum Computers Will Replace Digital Computers — BQP subsection