P vs NP problem
Determine whether the complexity classes P and NP are equal, thereby resolving the P versus NP problem.
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References
Proving similar exponential lower bounds for general Boolean circuits (which allow negations) would resolve the $\mathsf{P}$ vs $\mathsf{NP}$ problem, a major open question in computer science.
— The Story of Sunflowers
(2509.14790 - Rao, 18 Sep 2025) in Section 2.2 (Monotone circuit complexity)