Resolve P versus NP
Determine whether there exists a polynomial-time algorithm that solves all problems in NP; equivalently, prove or refute that any NP-complete problem admits a polynomial-time algorithm (i.e., resolve whether P equals NP).
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References
The computer science community largely believes that no polynomial time algorithm exists for all problems in NP (as an efficient algorithm for any of these complete problems, would imply), but this has yet to be proven.
— Entropy Computing, A Paradigm for Optimization in Open Photonic Systems
(2407.04512 - Nguyen et al., 5 Jul 2024) in Introduction (Section 1)