Overall efficiency of the proposed spatio-temporal Fourier synthesis methods

Determine the overall efficiency of the spatio-temporal Fourier synthesis deep-brain stimulation techniques that employ multiple electrode pairs with sinusoidal currents, including the capability to deliver effective stimulation to targeted deep-brain regions.

Background

The paper concludes by emphasizing that the overall efficiency of the various STFS-based stimulation strategies remains uncertain and requires further paper. Efficiency encompasses how well power is delivered to targeted deep-brain regions while maintaining tolerability.

This open question motivates systematic experimental investigations and optimization across waveform parameters, electrode pair placement, and skin sensitivity constraints.