Generalization of molecularly defined positive/negative prediction error neuron classes

Determine whether the molecularly defined subpopulations of layer 2/3 excitatory neurons that encode positive versus negative prediction errors in mouse V1 generalize to other cortical regions and to mismatch types beyond visuomotor paradigms.

Background

Cell-type–specific studies have identified transcriptionally defined subpopulations in L2/3 that differentially encode positive and negative prediction errors in a visuomotor mismatch task.

It remains unknown whether these molecular distinctions extend across cortical areas and apply to other mismatch conditions, which is crucial for evaluating cell-type–specific implementations of predictive processing.