The global communication pathways of the human brain transcend the cortical-subcortical-cerebellar division (2505.22893v2)

Abstract: Understanding how cortex, subcortex and cerebellum integrate is a major challenge for neuroscience, however, studies of the brain's structural connectivity have mostly focused on cortico-cortical links. Here, we used diffusion imaging to construct the structural connectome of the entire human brain including 360 cortical, 233 subcortical, and 125 cerebellar regions of interest (ROIs). We found that the brain forms a modular and hierarchical network architecture, organized into modules of mixed cortical, subcortical and/or cerebellar regions, and whose cross-modular pathways are centralized through highly connected hub ROIs (a `rich-club'). This global rich-club is subcortically dominated and, surprisingly, composed of hub ROIs from all subcortical structures rather than one region like the thalamus, centralizing the communication pathways. This study improves our understanding of the human brain's organization. It provides structural evidence to question the prevalent cortico-centric notion by revealing a connectome centered at the subcortex but made of transversal pathways.