Pulsatile Magnetized $Cu$-$Al_{2}O_{3}$/Casson Blood Flow Through an Elliptical Stenotic Artery for Drug Delivery Applications

Abstract: Among cardiovascular diseases, atherosclerosis is a primary cause of stenosis, involving the accumulation of plaques in the inner lining of an artery. Inspired by drug delivery applications, the proposed study aims to examine the numerical modeling of a two-dimensional, axisymmetric, and time-dependent hybrid nanofluid composed of copper $(Cu)$, alumina $(Al_{2}O_{3})$ nanoparticles, and blood as base fluid. Blood, modeled by the non-Newtonian Casson model, flows through an elliptical stenotic artery. The pulsatile nature of the pressure gradient and magnetic field impact with the Hall current parameter are also taken into account in this study. A finite difference technique, forward in time and central in space (FTCS), is deployed to numerically discretize the transformed dimensionless model using MATLAB. Comprehensive visualization of the effects of hemodynamic, geometric, and nanoscale parameters on transport characteristics, and extensive graphical results for blood flow characteristics are provided. A comparison is made among blood, regular nanofluid, and hybrid nanofluid to analyze their properties in relation to fluid flow and heat transfer. An augmentation in the non-Newtonian parameter results in an amplification of velocity and in a reduction of the temperature profile. Incorporating $Cu$ and $Al_2O_3$ nanoparticles into the fluid results in a decrease of velocity and an increase of temperature. These findings possess significant practical implications for applications where efficient heat transfer is essential, such as in drug delivery systems and the thermal management of biomedical devices. However, the observed reduction in velocity may necessitate modifications to flow conditions to ensure optimal operational performance in these contexts.