Calibration of highly segmented, compact gamma camera for Molecular Breast Imaging

Abstract: Breast cancers is the second leading cause of cancer mortality in women; early diagnosis increase the probability of a successful therapy; any marginal improvement in this direction helps sparing lives. In this context functional imaging techniques such as Molecular Breast Imaging (MBI) represents an important supplemental screening, especially in the more questionable cases. In order to further extend the MBI performances an innovative asymmetric dual detector device, with mixed optics has been recently proposed and prototyped; the sensors are highly segmented with a correspondingly large number of independent, configurable, electronic readout channels with self-triggering capability. This flexible electronics architecture has different advantages in addition to those related to the adopted asymmetric dual detector geometry: real-time event selection based on the adjustable gain and discriminator threshold at single channel (or group of channels) level; repeatable, quick hardware and software channel response equalization; configurable list mode acquisition for versatile offline image processing. These benefits come at the expenses of more complex calibration methods and optimization procedures, which are detailed in the present paper.