Determine whether Rule 110 supports universal self-replication
Determine whether the elementary cellular automaton Rule 110 belongs to the class UniversalSelfReplicating of cellular automata that support non-trivial self-replication by constructing or ruling out self-replicating structures that perform Turing-universal computation under Rule 110 dynamics.
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Many challenges remain. Determining whether specific CAs support universal self-replication is open, and Rule 110 presents a compelling test case: Conjecture Rule 110 is in \textnormal{\textsf{UniversalSelfReplicating}.}
— Self-replication and Computational Universality
(2510.08342 - Cotler et al., 9 Oct 2025) in Discussion