Identify more discriminating necessary conditions for universal self-replication
Develop additional, more discriminating necessary conditions—beyond local universality and the local self-replicating condition—that characterize when a cellular automaton can belong to the UniversalSelfReplicating class.
References
At the moment, we do not know of any other more discriminating necessary conditions, and we will discuss this later.
                — Self-replication and Computational Universality
                
                (2510.08342 - Cotler et al., 9 Oct 2025) in Section 'Open problems and conjectures' (Genericity of universality and self-replication)