Polynomial-time unknot detection
Determine whether there exists a polynomial-time algorithm that decides, given a knot diagram, whether it represents the unknot; equivalently, develop or rule out polynomial-time unknot recognition.
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References
It is a major open problem in knot theory whether there is a polynomial-time unknot detection algorithm.
— The unknotting number, hard unknot diagrams, and reinforcement learning
(2409.09032 - Applebaum et al., 13 Sep 2024) in Subsection “Hard unknot diagrams,” Section 1 (Introduction)