Mechanism and purpose of respirasome formation

Determine the assembly mechanisms and physiological functions of respiratory supercomplexes (respirasomes) in mitochondria, including how their formation affects electron transport efficiency, regulation, and ROS generation.

Background

Respiratory complexes can assemble into supercomplexes that may influence electron transport chain organization, kinetics, and ROS control.

Understanding why and how respirasomes form could reshape models of mitochondrial bioenergetics and pathology.

References

Although the mechanism and purpose of respirasome formation is not entirely clear [213, 214], respirasomes have functional implications for the properties of the respiratory chain.

— Physical Principles of Quantum Biology (2503.11747 - Babcock et al., 14 Mar 2025) in Chapter 2 - Quantum Electrodynamics: Lighting Up Life