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In vivo validation of the radical pair mechanism as a magnetic compass

Demonstrate in vivo whether the radical pair mechanism in cryptochrome constitutes the functional basis of a working magnetic compass in animals, by linking spin-dependent reaction dynamics to sensory transduction and behavior.

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Background

Cryptochrome-based radical pair dynamics provide a compelling framework for magnetoreception, with extensive in vitro evidence and behavioral correlates.

A conclusive in vivo demonstration connecting radical pair chemistry to sensory output and orientation behavior remains a key milestone.

References

Although the RPM provies an established basis for the magnetic sensitivity of many chemical reactions [435, 449] and magnetoreception in fruit flies and human cells has been shown to depend on the presence of cryptochrome, it remains to be demonstrated that the RPM can constitute the mechanism for a working chemical compass in vivo [425].

— Physical Principles of Quantum Biology (2503.11747 - Babcock et al., 14 Mar 2025) in Chapter 5 - Light Receptors, Spin Chemistry, & Cryptochrome