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Mechanism underlying arteriolar stenosis in CADASIL

Characterize the biological mechanisms that drive stenosis of cerebral arterioles in CADASIL.

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Background

Arteriolar stenosis is a prominent vascular abnormality in CADASIL and is associated with fibrosis of vessel walls. However, the precise mechanisms producing stenosis remain incompletely defined.

Clarifying the mechanism is essential for designing targeted interventions to prevent or reverse stenosis and its downstream consequences, including ischemia.

References

The mechanism of stenosis in the arterioles of CADASIL patients is not entirely understood, but fibrosis of the vessel walls does appear to be a common symptom [23].

— Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL): Immunotherapy and Cell Therapy approaches (2506.09293 - Haile et al., 10 Jun 2025) in CADASIL as a Candidate for Cell and Gene Therapy