Infinitude of Mersenne primes
Determine whether there are infinitely many primes of the form 2^n − 1 (Mersenne primes), equivalently whether Euclid’s construction yields infinitely many even perfect numbers of the form (2^n − 1)·2^{n−1} with 2^n − 1 prime.
References
But even today we do not know if there are infinitely many numbers in Euclid's family, because we do not know if there are infinitely many primes 2{n}-1.
— How did Fermat discover his theorem?
(2502.11165 - Pengelley, 16 Feb 2025) in Subsection “Perfect Numbers”