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Effect of inactivity on EAA‑mediated mTORC1 signaling and muscle protein synthesis is poorly characterized

Determine how physical inactivity (e.g., bed rest) affects essential amino acid–induced amino acid transporter expression, mTORC1 signaling, and skeletal muscle protein synthesis in adults across age groups.

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Background

Essential amino acids promote MPS via amino acid transporters and mTORC1 signaling, yet the extent to which inactivity blunts these responses is not well defined. This gap limits countermeasure design for periods of immobilization or reduced activity.

References

It's surprising to note that we don't have much info on how inactivity affects this process despite it being crucial for muscle mass maintenance.

— The Interplay Between Physical Activity, Protein Consumption, and Sleep Quality in Muscle Protein Synthesis (2410.16169 - Devkota et al., 21 Oct 2024) in Section: THE ROLE OF SLEEP AND RECOVERY