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Impact of non‑leucine essential amino acids on muscle protein synthesis remains unknown

Determine the specific effects of essential amino acids other than leucine on human skeletal muscle protein synthesis at rest and in response to resistance exercise, including quantification of dose–response relationships and potential synergistic interactions.

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Background

The review notes that leucine has been extensively studied for its role in stimulating muscle protein synthesis (MPS), whereas evidence for other essential amino acids (EAAs) is scarce. Clarifying the independent and combined effects of non‑leucine EAAs on MPS would inform formulation of protein supplements and dietary strategies for different populations (e.g., young vs. older adults, trained vs. untrained).

References

Leucine, in particular, is largely studied for its influential role in stimulating MPS. On the other hand, the impact of other EAA’s remains unknown due to limited data [37][36].

— The Interplay Between Physical Activity, Protein Consumption, and Sleep Quality in Muscle Protein Synthesis (2410.16169 - Devkota et al., 21 Oct 2024) in Introduction