Cause of age‑related slowing of muscle protein synthesis is unclear

Ascertain whether the observed reduction in skeletal muscle protein synthesis rates in older adults relative to younger adults is attributable to reduced physical activity levels or to intrinsic age‑related factors independent of activity.

Background

The authors highlight that older adults show slower MPS compared to younger adults, but the causal driver remains unresolved. Disentangling the roles of habitual activity versus age‑intrinsic physiology is essential for designing interventions to counteract sarcopenia.