Existence of intrinsic charm in the proton
Determine whether the proton contains intrinsic charm, meaning charm-quark parton distributions not generated exclusively by perturbative gluon splitting, and assess whether such a component can produce a charm–anticharm asymmetry.
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Another open question is the existence of intrinsic charm quarks. In the language of PDFs, this would mean that the charm-quark PDFs would not only be generated perturbatively through $g \rightarrow c \Bar{c}$ splittings. Intrinsic charm could manifest another asymmetry, $c\neq \Bar{c}$ .
Moreover, DIS can be used to answer unresolved questions about PDFs, e.g. whether the proton has an intrinsic charm component.
Another cause of intrigue is the question of whether the wavefunction of the proton has an intrinsic contribution from the charm quark, which is a long-standing open question, which would be a significant discovery about the fundamental structure of the proton as the charm quark is $\sim 36\%$ more massive than the proton itself. Allowing for intrinsic charm in this formalism is in principle possible, for example based on Ref., but is left for future work.