Separate temperature, pH, and magnetic noise in vivo

Determine how to reliably separate temperature, pH, and magnetic-noise contributions to quantum-sensor responses in complex in-vivo environments.

Background

The paper explains that different environmental variables can produce overlapping effects in quantum-sensing measurements. Temperature and magnetic fields can both shift optically detected magnetic resonance resonances, fluctuating paramagnetic species primarily affect longitudinal relaxation, and chemically transduced quantities such as pH can introduce additional cross-sensitivity.

Although simultaneous temperature and magnetic-field measurements and Bayesian or machine-learning approaches for joint inference have been demonstrated, the authors state that reliable separation of temperature, pH, and magnetic noise in complex living systems has not been resolved. This issue is central to obtaining specific, quantitative biomedical measurements rather than ambiguous sensor responses.

References

Reliable separation of temperature, pH, and magnetic noise in complex in-vivo environments, however, remains unresolved.

— From Solid-State Spin Defects to Fluorescent Proteins: A Perspective on Quantum Optical Sensing Platforms for Biomedical Applications  (2610.11644 - Parhi et al., 8 Oct 2026) in Section 3, subsection “Tissue and complex biological systems”