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Precise Pathogenesis of Cervical and Endometrial Cancers Unknown

Establish the precise pathogenesis of cervical cancer and endometrial carcinoma by delineating the etiological mechanisms and sequence of molecular events that lead to tumor initiation and progression in each disease.

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Background

Cervical cancer (CC) and endometrial carcinoma (EC) are among the most prevalent gynecological malignancies, with noted associations such as links to human papillomavirus infection and, for EC, sex hormone involvement. Despite prior etiological studies, the exact mechanisms driving these cancers have not been fully clarified.

The paper motivates an integrated bioinformatics approach to discover shared genetic biomarkers and candidate drugs, in part because establishing the precise pathogenesis remains an unresolved need for improving early diagnosis and targeted therapy.

References

The precise pathogenesis of these two forms of cancer is still unknown, despite several earlier studies on their etiology.

— Identification of Shared Genetic Biomarkers to Discover Candidate Drugs for Cervical and Endometrial Cancer by Using the Integrated Bioinformatics Approaches (2510.22174 - Reza et al., 25 Oct 2025) in Section 1 (Introduction)