Ascertain unknown etiologic factors in primary osteoporosis

Ascertain the etiologic factors responsible for cases of primary osteoporosis that are not attributable to aging or menopause, specifying the biological mechanisms underlying these idiopathic presentations.

Background

The paper distinguishes primary from secondary osteoporosis based on etiology, noting that primary osteoporosis can be associated with aging or menopause but may also occur without an identifiable cause. This lack of a defined etiology for some cases indicates an unresolved question regarding underlying mechanisms.

Identifying the specific factors driving idiopathic primary osteoporosis would improve risk stratification, prevention strategies, and treatment development beyond the current symptomatic approaches.