Origin and hierarchy of elementary particle masses
Determine the precise mechanism by which the Higgs field generates masses for elementary particles in the Standard Model and explain why different particles acquire different masses, thereby resolving the open problem of the origin and hierarchy of particle masses.
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References
But, despite the work of thousands of researchers, it is not clear exactly how it works and why some particles are more massive than others. Therefore, the problem of particle masses remains open.
— The 1932 Majorana equation: a forgotten but surprisingly modern particle theory
(2404.01357 - Nanni, 1 Apr 2024) in Section 4, The Problem of Particle Masses