Molecular factors governing centrosomal actin nucleation during MTOC reorientation

Elucidate the molecular factors that govern actin nucleation around the centrosome during microtubule-organizing center (MTOC) reorientation in cell division, to define the mechanisms by which the centrosome orchestrates actin assembly in this context.

Background

Recent findings indicate that actin nucleation occurs around the centrosome during MTOC reorientation in cell division, reinforcing the concept of the centrosome as an organizing center for cytoskeletal components.

Despite these insights, the specific molecular determinants and pathways that drive centrosome-proximal actin nucleation during reorientation remain to be identified, motivating targeted experimental and theoretical studies.